This is really confusing.
How you set AdPlugg up is going to dependent on your business and what you are looking to do. AdPlugg can serve ads to any type of website, to video players, emails, etc. You can also use AdPlugg as an advertiser to manage and track the ads that you are running on someone else's site. You can use AdPlugg to serve a variety of ad formats including image ads, HTML5 ads, popup ads, etc. And your ads can come from any source including direct sold, ad networks, affiliate networks, etc.
Probably the best place to start is at the AdPlugg Cookbook. The AdPlugg Cookbook has easy-to-follow "recipes" for just about any type of setup that you might be looking for. If you don't see something there, let us know and we can add a recipe!
If you have special needs or would like personalized help, please feel free to contact us with what you are trying to do and we can help you to get things set up.